Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related
neurodegenerative diseases characterized by prominent neurodegeneration in selective …

Bromodeoxyuridine (BrdU) is a thymidine analog that incorporates DNA of dividing cells
during the S-phase of the cell cycle. As such, BrdU is used for birth dating and monitoring …

Nonstandard abbreviations used: reactive oxygen species (ROS); Alzheimer disease (AD);
superoxide (O2•–); hydrogen peroxide (H2O2); superoxide dismutase (SOD); β-amyloid …

Neurogenesis in adult primate neocortex: an evaluation of the evidence | Nature Reviews
Neuroscience Skip to main content Thank you for visiting nature.com. You are using a browser …

Gradual disclosure of the molecular basis of selective neuronal apoptosis during
neurodegenerative diseases reveals active participation of acetylating and deacetylating …

Harlequin (Hq) mutant mice have progressive degeneration of terminally differentiated
cerebellar and retinal neurons. We have identified the Hq mutation as a proviral insertion in …

As a sequel of brain ischemia, selective neuronal loss (SNL)—as opposed to pannecrosis
(ie infarction)—is attracting growing interest, particularly because it is now detectable in vivo …

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …