Biosynthetic modifications of the 6/10-bicyclic hydrocarbon skeletons of the eunicellane
family of diterpenoids are unknown. We explored the biosynthesis of a bacterial trans …

Eunicellane diterpenoids are a remarkable family of terpene natural products and have
been of high interest for over five decades. Widely distributed in soft corals and rare in …

Eunicellane diterpenoids, containing a typical 6, 10-bicycle, are bioactive compounds widely
present in marine corals, but rarely found in bacteria and plants. The intrinsic macrocycle …

During gliotoxin biosynthesis in fungi, the cytochrome P450 GliF enzyme catalyzes an
unusual C–N ring-closure step while also an aromatic ring is hydroxylated in the same …

The natural products terpenoids are widely distributed in animals (marine invertebrates),
plants, microorganisms, with diverse molecular structures for bioactivities. A large number of …

Meroterpenoids are hybrid natural products that arise from the integration of terpenoid and
non-terpenoid biosynthetic pathways. While the biosynthesis of fungal meroterpenoids …

Meroterpenoid clavilactones feature a unique benzo-fused ten-membered carbocyclic ring
unit with an α, β-epoxy-γ-lactone moiety, forming an intriguing 10/5/3 tricyclic nested …

Many complex terpenoids, predominantly isolated from plants and fungi, show drug-like
physicochemical properties. Recent advances in genome mining revealed actinobacteria as …

In this study, we constructed a taxadiene overproduction platform and identified a
cytochrome P450, CYP701A8, that activates the inert C–H bonds in taxadiene to produce …

Heterologous expression of an atr terpenoid gene cluster derived from Streptomyces atratus
Gö66 in S. albus J1074 led to the discovery of three novel labdane diterpenoids featuring …