Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

Drug candidate and toxicity screening processes currently rely on results from early-stage in
vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

Advances in molecular biology and toxicology are paving the way for major improvements in
the evaluation of the hazards posed by the large number of chemicals found at low levels in …

Since time immemorial, human beings have sought natural medications for treatment of
various diseases. Weighty evidence demonstrates the use of chemical methodologies for …

Herbs and herb-derived medicines have played a crucial role in health and disease man‐-
agement for many centuries. Many ancient civilizations show documented evidence for the …

Cellular populations have been widely observed to respond heterogeneously to
perturbation. However, interpreting the observed heterogeneity is an extremely challenging …

Despite extensive research into the biomedical and pharmaceutical applications of
nanoparticles, and the liver being the main detoxifying organ in the human body, there are …

Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to
inadequacy of current preclinical screening assays, but recently established rodent models …

Salcaprozate sodium (SNAC) and sodium caprate (C 10) are the two leading intestinal
permeation enhancers (PEs) in oral peptide formulations in clinical trials. There is debate …