Interstitial cells: regulators of smooth muscle function

KM Sanders, SM Ward, SD Koh - Physiological reviews, 2014 - journals.physiology.org
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

Mechanics of the stomach: A review of an emerging field of biomechanics

S Brandstaeter, SL Fuchs, RC Aydin… - GAMM …, 2019 - Wiley Online Library
Mathematical and computational modeling of the stomach is an emerging field of
biomechanics where several complex phenomena, such as gastric electrophysiology, fluid …

Chaste: an open source C++ library for computational physiology and biology

GR Mirams, CJ Arthurs, MO Bernabeu… - PLoS computational …, 2013 - journals.plos.org
Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

A multiscale model of the electrophysiological basis of the human electrogastrogram

P Du, G O'Grady, LK Cheng, AJ Pullan - Biophysical journal, 2010 - cell.com
The motility of the stomach is coordinated by an electrical activity termed" slow waves", and
slow-wave dysrhythmias contribute to motility disorders. One major method for clinically …

On a coupled electro-chemomechanical model of gastric smooth muscle contraction

L Klemm, R Seydewitz, M Borsdorf, T Siebert, M Böl - Acta biomaterialia, 2020 - Elsevier
The stomach is a central organ in the gastrointestinal tract that performs a variety of
functions, in which the spatio-temporal organisation of active smooth muscle contraction in …

Biophysically based modeling of the interstitial cells of Cajal: current status and future perspectives

R Lees-Green, P Du, G O'Grady, A Beyder… - Frontiers in …, 2011 - frontiersin.org
Gastrointestinal motility research is progressing rapidly, leading to significant advances in
the last 15 years in understanding the cellular mechanisms underlying motility, following the …

[HTML][HTML] Three-dimensional multi-field modelling of gastric arrhythmias and their effects on antral contractions

L Klemm, R Seydewitz, T Siebert, M Böl - Computers in Biology and …, 2023 - Elsevier
The contraction activation of smooth muscle in the stomach wall (SW) is coordinated by slow
electrical waves. The interstitial cells of Cajal (ICC), specialised pacemaker cells, initiate and …

Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility

P Du, G O'Grady, J Gao, S Sathar… - … : Systems Biology and …, 2013 - Wiley Online Library
Experimental progress in investigating normal and disordered gastric motility is increasingly
being complimented by sophisticated multiscale modeling studies. Mathematical modeling …

Slow wave propagation and plasticity of interstitial cells of Cajal in the small intestine of diabetic rats

WJEP Lammers, HM Al‐Bloushi… - Experimental …, 2011 - Wiley Online Library
The number of myenteric interstitial cells of Cajal (ICC‐MY), responsible for the generation
and propagation of the slow wave in the small intestine, has been shown to decrease in …

Localized gastric distension disrupts slow-wave entrainment leading to temporary ectopic propagation: a high-resolution electrical mapping study

CHA Chan, Z Aghababaie… - American Journal …, 2021 - journals.physiology.org
Gastric distension is known to affect normal slow-wave activity and gastric function, but links
between slow-wave dysrhythmias and stomach function are poorly understood. Low …