Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
Site specific N-and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concern
The glycosylation on the spike (S) protein of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, modulates the viral infection …
coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, modulates the viral infection …
Mechanisms of allostery at the viral surface through the eyes of molecular simulation
The outermost surface layer of any virus is formed by either a capsid shell or envelope. Such
layers have traditionally been thought of as immovable structures, but it is becoming …
layers have traditionally been thought of as immovable structures, but it is becoming …
Restoring protein glycosylation with GlycoShape
Despite ground-breaking innovations in experimental structural biology and protein structure
prediction techniques, capturing the structure of the glycans that functionalize proteins …
prediction techniques, capturing the structure of the glycans that functionalize proteins …
Combinatorial Approach with Mass Spectrometry and Lectin Microarray Dissected Site-Specific Glycostem and Glycoleaf Features of the Virion-Derived Spike Protein …
The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has impacted public health globally. As the …
syndrome coronavirus 2 (SARS-CoV-2), has impacted public health globally. As the …
Analysis of the N-glycosylation profiles of the spike proteins from the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2
N-Glycosylation plays an important role in the structure and function of membrane and
secreted proteins. Viral proteins used in cell entry are often extensively glycosylated to assist …
secreted proteins. Viral proteins used in cell entry are often extensively glycosylated to assist …
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries
Most membrane proteins are modified by covalent addition of complex sugars through N-
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
[HTML][HTML] Evolving spike-protein N-glycosylation in SARS-CoV-2 variants
Abstract Since> 3 years, SARS-CoV-2 has plunged humans into a colossal pandemic.
Henceforth, multiple waves of infection have swept through the human population, led by …
Henceforth, multiple waves of infection have swept through the human population, led by …
Analysis of N‐ and O‐linked site‐specific glycosylation by ion mobility mass spectrometry: State of the art and future directions
M Girgis, G Petruncio, P Russo, S Peyton, M Paige… - …, 2024 - Wiley Online Library
Glycosylation, the major post‐translational modification of proteins, significantly increases
the diversity of proteoforms. Glycans are involved in a variety of pivotal structural and …
the diversity of proteoforms. Glycans are involved in a variety of pivotal structural and …
Many roles of carbohydrates: A computational spotlight on the coronavirus S protein binding
Glycosylation is one of the post-translational modifications with more than 50% of human
proteins being glycosylated. The exact nature and chemical composition of glycans are …
proteins being glycosylated. The exact nature and chemical composition of glycans are …