RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …
Inhibition of RNA-binding proteins with small molecules
P Wu - Nature Reviews Chemistry, 2020 - nature.com
Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …
dysregulated, can lead to a range of human diseases. The identification of small molecules …
The RNA-binding protein HuR in human cancer: a friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
HuR as a molecular target for cancer therapeutics and immune-related disorders
M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
[HTML][HTML] Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
RNA-binding proteins in cancer drug discovery
JB Bertoldo, S Müller, S Hüttelmaier - Drug discovery today, 2023 - Elsevier
Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
[HTML][HTML] HuR controls glutaminase RNA metabolism
D Adamoski, L M. dos Reis, ACP Mafra… - Nature …, 2024 - nature.com
Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target
for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) …
for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) …
Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge
Abstract Salvia miltiorrhiza Bunge (Danshen), a famous traditional Chinese herb, has been
used clinically for the treatment of various diseases for centuries. Document data showed …
used clinically for the treatment of various diseases for centuries. Document data showed …
[HTML][HTML] HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
M Palomo-Irigoyen, E Pérez-Andrés… - The Journal of …, 2020 - Am Soc Clin Investig
Cancer cells can develop a strong addiction to discrete molecular regulators, which control
the aberrant gene expression programs that drive and maintain the cancer phenotype. Here …
the aberrant gene expression programs that drive and maintain the cancer phenotype. Here …