Therapies for thoracic aortic aneurysms and acute aortic dissections: old controversies and new opportunities
DM Milewicz, F Ramirez - Arteriosclerosis, Thrombosis, and …, 2019 - Am Heart Assoc
Thoracic aortic aneurysms that progress to acute aortic dissections are often fatal. Thoracic
aneurysms have been managed with treatment with β-adrenergic blocking agents (β …
aneurysms have been managed with treatment with β-adrenergic blocking agents (β …
The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients
Contemporary analyses focused on a limited number of clinical and molecular biomarkers
have been unable to accurately predict clinical outcomes in pancreatic ductal …
have been unable to accurately predict clinical outcomes in pancreatic ductal …
Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies
Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …
Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation
MJ Ruiz-Rodríguez, J Oller… - EMBO Molecular …, 2024 - embopress.org
Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition associated
with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various …
with Marfan syndrome (MFS), a disease caused by fibrillin-1 gene mutations. While various …
Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection …
Aging-induced functional and phenotypic alterations of the vasculature (eg, endothelial
dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It …
dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It …
Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions
Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for
significant morbidity and mortality. Advances in medical genetics and imaging have …
significant morbidity and mortality. Advances in medical genetics and imaging have …
Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT
EM Rabie, SX Zhang, CE Dunn… - Molecular biology of the …, 2021 - Am Soc Cell Biol
Abscission is the final stage of cytokinesis during which the parent cell physically separates
to yield two identical daughters. Failure of abscission results in multinucleation (MNC), a …
to yield two identical daughters. Failure of abscission results in multinucleation (MNC), a …
FN (fibronectin)-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome
Background: Marfan syndrome, caused by mutations in the gene for fibrillin-1, leads to
thoracic aortic aneurysms (TAAs). Phenotypic modulation of vascular smooth muscle cells …
thoracic aortic aneurysms (TAAs). Phenotypic modulation of vascular smooth muscle cells …
Lineage-specific induced pluripotent stem cell–derived smooth muscle cell modeling predicts integrin alpha-V antagonism reduces aortic root aneurysm formation in …
K Nakamura, AR Dalal, N Yokoyama… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: The role of increased smooth muscle cell (SMC) integrin αv signaling in Marfan
syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism and …
syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism and …
[HTML][HTML] Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice
Mechanisms whereby fibrillin-1 mutations determine thoracic aorta aneurysms/dissections
(TAAD) in Marfan Syndrome (MFS) are unclear. Most aortic aneurysms evolve from …
(TAAD) in Marfan Syndrome (MFS) are unclear. Most aortic aneurysms evolve from …