HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
More tricks with tetramers: a practical guide to staining T cells with peptide–MHC multimers
Analysis of antigen‐specific T‐cell populations by flow cytometry with peptide–MHC (pMHC)
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …
SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses
LK Vibholm, SSF Nielsen, MH Pahus, GS Frattari… - …, 2021 - thelancet.com
Abstract Background Upon SARS-CoV-2 infection, most individuals develop neutralizing
antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 …
antibodies and T-cell immunity. However, some individuals reportedly remain SARS-CoV-2 …
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes
Identification of the peptides recognized by individual T cells is important for understanding
and treating immune-related diseases. Current cytometry-based approaches are limited to …
and treating immune-related diseases. Current cytometry-based approaches are limited to …
Mass cytometry detects H3. 3K27M-specific vaccine responses in diffuse midline glioma
S Mueller, JM Taitt… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND Patients with diffuse midline gliomas (DMGs), including diffuse intrinsic
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …
Antibodies against immune checkpoint molecules restore functions of tumor-infiltrating T cells in hepatocellular carcinomas
G Zhou, D Sprengers, PPC Boor, M Doukas, H Schutz… - Gastroenterology, 2017 - Elsevier
Background & Aims Ligand binding to inhibitory receptors on immune cells, such as
programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4) …
programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4) …
Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection
Y Sun, L Yan, J Sun, M Xiao, W Lai, G Song… - Nature …, 2022 - nature.com
Peptide-MHC (pMHC) multimers have excelled in the detection of antigen-specific T cells
and have allowed phenotypic analysis using other reagents, but their use for detection of …
and have allowed phenotypic analysis using other reagents, but their use for detection of …
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …
as a pathway involved in the development of autoimmunity. However, the mechanisms that …