The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Simple Summary Multiple myeloma (MM) is a still uncurable tumor of mainly elderly patients
originating from the terminally differentiated B cells. Introduction to the treatment of MM …

Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high
incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs …

Background Recent studies have shown that ubiquitin‐mediated cell apoptosis can
modulate protein interaction and involve in the progress of oocyte maturation and …

Eukaryotic life depends upon the interplay between vast networks of signaling pathways
composed of upwards of 109–1010 proteins per cell. The integrity and normal operation of …

Background The conserved sirtuin protein sirtuin 3 (SIRT3) is a vital protective protein for
cardiac hypertrophy. Inhibition of SIRT3 accelerated the development of heart hypertrophy …

Introduction: Luteolin is a flavonoid polyphenolic compound exerting broad pharmacological
and medicinal properties. Diabetes-related obesity increases the total blood volume and …

Diabetic retinopathy (DR) is the most common complication of diabetes, being the most
prevalent reason for blindness among the working-age population in the developed world …