The renin‐angiotensin system (RAS) is classically known for its role in regulation of blood
pressure, fluid and electrolyte balance. Recently, several local RASs in organs such as …

The renin-angiotensin system has long been recognized as an important regulator of
systemic blood pressure and renal electrolyte homeostasis, and local renin-angiotensin …

Increased plasma concentrations of angiotension II (Ang II) have been implicated in
atherogenesis. To examine this relationship directly, we infused Ang II or vehicle for 1 month …

Overfeeding of rodents leads to increased local formation of angiotensin II due to increased
secretion of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte …

Obesity is a leading cause of death worldwide because of its associated inflammatory
disorders such as hypertension, cardiovascular and kidney diseases, dyslipidemia, glucose …

The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of
cardiovascular function and hydromineral balance) has regained the spotlight for its …

MicroRNAs play an important role in myocardial diseases. MiR‐133a regulates cardiac
hypertrophy, while miR‐29b is involved in cardiac fibrosis. The aim of this study was to …

Leptin is a 16-kDa protein secreted by white adipose tissue that is primarily involved in the
regulation of food intake and energy expenditure. Plasma leptin concentration is …

Excessive accumulation of adipose tissue is associated with profound alterations in the
cardiovascular system, including an increase in systemic blood pressure. It now appears …

We previously showed that angiotensin II (ang II) infusion in the rat produces cachexia and
decreases circulating insulin-like growth factor I (IGF-I). The weight loss derives from an …