Intravital fluorescence microscopy enables the direct imaging of fluorophores in vivo and
advanced techniques such as fluorescence lifetime imaging (FLIM) enable the simultaneous …

Background: The clinical application of fluorescent contrast agents (fluorescein, indocyanine
green, and aminolevulinic acid) with intraoperative microscopy has led to advances in …

In brain tumor surgery, recognition of tumor boundaries is key. However, intraoperative
assessment of tumor boundaries by the neurosurgeon is difficult. Therefore, there is an …

In this perspective, we discuss how the nonlinear optical technique of second-harmonic
generation (SHG) microscopy has been used to greatly enhance our understanding of the …

Second-harmonic generation microscopy represents an important tool to evaluate
extracellular matrix collagen structure, which undergoes changes during cancer …

Thin tissue sections of normal and tumorous pancreatic tissues stained with hematoxylin
and eosin were investigated using multiphoton excitation fluorescence (MPF), second …

Aging and diabetes are associated with increased low‐back pain and intervertebral disk
(IVD) degeneration yet causal mechanisms remain uncertain. Advanced glycation end …

Triple negative breast cancer (TNBC) is a highly aggressive form of cancer. Detecting TNBC
early is crucial for improving disease prognosis and optimizing treatment. Unfortunately …

The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory
cycle. Maturation of the ovarian follicle, release of the oocyte in the course of ovulation as …

Nonlinear optics, which is a subject for studying the interaction between intense light and
materials, has great impact on various research fields. Since many structures in biological …