[HTML][HTML] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

AP Fan, H An, F Moradi, J Rosenberg, Y Ishii, T Nariai… - Neuroimage, 2020 - Elsevier
Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

[HTML][HTML] Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults

S Deng, CG Franklin, M O'Boyle, W Zhang, BL Heyl… - Neuroimage, 2022 - Elsevier
Voxel-based physiological (VBP) variables derived from blood oxygen level dependent
(BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF) …

Challenges and perspectives of the hybridization of PET with functional MRI or ultrasound for neuroimaging

N Tournier, C Comtat, V Lebon, JL Gennisson - Neuroscience, 2021 - Elsevier
Hybridization of positron emission tomography (PET) with other functional neuroimaging
techniques such as functional magnetic resonance imaging (fMRI) or functional ultrasound …

[HTML][HTML] Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI: Impacts of arterial transit time, labeling efficiency, and hematocrit

MY Zhao, AP Fan, DYT Chen, MJ Sokolska, J Guo… - Neuroimage, 2021 - Elsevier
Cerebrovascular reactivity (CVR) reflects the capacity of the brain to meet changing
physiological demands and can predict the risk of cerebrovascular diseases. CVR can be …

Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI

MY Zhao, AP Fan, DYT Chen, Y Ishii… - Journal of Cerebral …, 2022 - journals.sagepub.com
Cerebrovascular reactivity (CVR) reflects the CBF change to meet different physiological
demands. The reference CVR technique is PET imaging with vasodilators but is …

[HTML][HTML] Use of real-time phase-contrast MRI to quantify the effect of spontaneous breathing on the cerebral arteries

P Liu, S Fall, O Balédent - NeuroImage, 2022 - Elsevier
Quantification of the effect of breathing on the cerebral circulation provides a better
mechanistic understanding of the brain's circulatory system and is important in the early …

Predicting 15O-Water PET cerebral blood flow maps from multi-contrast MRI using a deep convolutional neural network with evaluation of training cohort bias

J Guo, E Gong, AP Fan, M Goubran… - Journal of Cerebral …, 2020 - journals.sagepub.com
To improve the quality of MRI-based cerebral blood flow (CBF) measurements, a deep
convolutional neural network (dCNN) was trained to combine single-and multi-delay arterial …

Predicting PET cerebrovascular reserve with deep learning by using baseline MRI: a pilot investigation of a drug-free brain stress test

DYT Chen, Y Ishii, AP Fan, J Guo, MY Zhao… - Radiology, 2020 - pubs.rsna.org
Background Cerebrovascular reserve (CVR) may be measured by using an acetazolamide
test to clinically evaluate patients with cerebrovascular disease. However, acetazolamide …

A noninvasive method for quantifying cerebral metabolic rate of oxygen by hybrid PET/MRI: validation in a porcine model

L Narciso, T Ssali, L Liu, H Biernaski… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO2) is PET;
however, it is an invasive and complex procedure that also requires correction for …

Early-frame [18F] florbetaben PET/MRI for cerebral blood flow quantification in patients with cognitive impairment: comparison to an [15O] water gold standard

A Fettahoglu, M Zhao, M Khalighi… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Cerebral blood flow (CBF) may be estimated from early-frame PET imaging of lipophilic
tracers, such as amyloid agents, enabling measurement of this important biomarker in …