Pharmacology and toxicology are part of a much broader effort to understand the
relationship between chemistry and biology. While biomedicine has necessarily focused on …

As the current paradigms of drug discovery evolve, it has become clear that a more
comprehensive understanding of the interactions between small molecules and organismal …

Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …

Sustaining a balanced intestinal microbial community is critical for maintaining intestinal
health and preventing chronic inflammation. The gut is a highly dynamic environment …

The zebrafish represents an excellent compromise between system complexity and practical
simplicity, features that make it useful for modeling and mechanistic analysis of complex …

Copper ions are essential for biological function yet are severely detrimental when present
in excess. At the molecular level, copper ions catalyze the production of hydroxyl radicals …

Prolonged ingestion of a cholesterol-or saturated fatty acid-enriched diet induces chronic,
often systemic, auto-inflammatory responses resulting in significant health problems …

The zebrafish has become an important in vivo model in biomedical research. Effective
methods must be developed and utilized to deliver compounds or agents in solutions for …

Background and aims Autism spectrum disorder (ASD) is currently estimated to affect more
than 1% of the world population. For people with ASD, gastrointestinal (GI) distress is a …

Motility patterns in the mature intestine require the coordinated interaction of enteric
neurons, gastrointestinal smooth muscle, and interstitial cells of Cajal. In Hirschsprung's …