The hyaluronan/CD44 axis: a double-edged sword in cancer

N Cirillo - International Journal of Molecular Sciences, 2023 - mdpi.com
Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its
activation promotes stemness. Recent evidence shows that overexpression of CD44 is …

Cancer stem cells: an insight into the development of metastatic tumors and therapy resistance

T Nairuz, Z Mahmud, RK Manik, Y Kabir - Stem Cell Reviews and Reports, 2023 - Springer
The term “cancer stem cells”(CSCs) refers to cancer cells that exhibit traits parallel to normal
stem cells, namely the potential to give rise to every type of cell identified in a tumor …

Unmasking the deceptive nature of cancer stem cells: The role of cd133 in revealing their secrets

J Pospieszna, H Dams-Kozlowska, W Udomsak… - International Journal of …, 2023 - mdpi.com
Cancer remains a leading cause of death globally, and its complexity poses a significant
challenge to effective treatment. Cancer stem cells and their markers have become key …

High OCT4 expression might be associated with an aggressive phenotype in rectal cancer

L Lambis-Anaya, M Fernández-Ruiz, Y Liscano… - Cancers, 2023 - mdpi.com
Simple Summary The oncofetal protein OCT4 is a factor that promotes self-renewal and
maintenance of pluripotency of embryonic stem cells and induced stem cells, which has …

Prognostic value of PD‑L1 expression and CD68 macrophages in tumor nest of patients with primary gastric cancer

Y Zou, J Wang, J Zhang, Q Guo… - Oncology …, 2024 - spandidos-publications.com
The programmed death receptor 1/programmed death receptor ligand 1 axis (PD‑1/PD‑L1)
is involved in tumor immune escape and is a potential prognostic biomarker and anti‑tumor …

Emerging trends in immunotoxin targeting cancer stem cells

BZ Sibuh, R Gahtori, N Al-Dayan, K Pant, BF Far… - Toxicology in Vitro, 2022 - Elsevier
Cancer stem cells (CSCs) are self-renewing multipotent cells that play a vital role in the
development of cancer drug resistance conditions. Various therapies like conventional …

Stem cells and cancer stem cells: the Jekyll and Hyde scenario and their implications in stem cell therapy

WS Wan Kamarul Zaman, AA Nurul, F Nordin - Biomedicines, 2021 - mdpi.com
“Jekyll and Hyde” refers to persons with an unpredictably dual personality, who are battling
between good and evil within themselves In this regard, even cells consist of good and evil …

Clinicopathological significance of cancer stem cell markers (OCT-3/4 and SOX-2) in oral submucous fibrosis and oral squamous cell carcinoma

DC Venugopal, CL Caleb, NP Kirupakaran… - Biomedicines, 2023 - mdpi.com
Oral submucous fibrosis (OSMF) is highly prevalent in South East Asia with higher rates of
malignant transformation in Indian subcontinent. Numerous biomarkers are now being …

Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression

M Chakravarti, S Bera, S Dhar, A Sarkar… - Molecular Cancer …, 2024 - AACR
Targeting exhausted CD8+ T-cell (TEX)–induced aggravated cancer stem cells (CSC) holds
immense therapeutic potential. In this regard, immunomodulation via Neem Leaf …

Cordycepin Triphosphate as a Potential Modulator of Cellular Plasticity in Cancer via cAMP-Dependent Pathways: An In Silico Approach

JL Gonzalez-Llerena, BA Espinosa-Rodriguez… - International Journal of …, 2024 - mdpi.com
Cordycepin, or 3′-deoxyadenosine, is an adenosine analog with a broad spectrum of
biological activity. The key structural difference between cordycepin and adenosine lies in …