[HTML][HTML] The protein and microRNA cargo of extracellular vesicles from parasitic helminths–current status and research priorities

J Sotillo, MW Robinson, MJ Kimber, M Cucher… - International journal for …, 2020 - Elsevier
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which
is largely due to their secretion of molecules with immunomodulatory properties. Although …

[HTML][HTML] microRNAs: critical players during helminth infections

M Rojas-Pirela, D Andrade-Alviárez, W Quiñones… - Microorganisms, 2022 - mdpi.com
microRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression
post-transcriptionally through their interaction with the 3′ untranslated regions (3′ UTR) of …

[HTML][HTML] Role of Fasciola hepatica Small RNAs in the Interaction With the Mammalian Host

S Fontenla, M Langleib… - Frontiers in Cellular …, 2022 - frontiersin.org
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression being
involved in many different biological processes and play a key role in developmental timing …

microRNA silencing in a whole worm cestode model provides insight into miR-71 function

A Grecco, N Macchiaroli, MG Pérez, A Casulli… - International Journal for …, 2023 - Elsevier
Parasites belonging to the class Cestoda include zoonotic species such as Echinococcus
spp. and Taenia spp. that cause morbidity and mortality in endemic areas, mainly affecting …

[HTML][HTML] Nematode microRNAs can individually regulate interferon regulatory factor 4 and mTOR in differentiating T helper 2 lymphocytes and modulate cytokine …

J Soichot, N Guttmann, H Rehrauer, N Joller… - Frontiers in Molecular …, 2022 - frontiersin.org
Parasitic nematodes are masterful immunomodulators. This class of pathogens has evolved
a spectrum of sophisticated strategies to regulate and evade host immune responses …

[HTML][HTML] Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D

Y Liao, Z Zhu, Y Liu, J Wu, D Li, Z Li, J Xu… - Cell Communication and …, 2023 - Springer
Background Macrophages and neutrophils are rapidly recruited around Schistosome eggs
to form granulomas. Extracellular traps (ETs) of macrophages and neutrophils are part of the …

The challenging world of extracellular RNAs of helminth parasites

MA Cucher, ME Ancarola, L Kamenetzky - Molecular immunology, 2021 - Elsevier
In the last years, cell free or extracellular RNAs (ex-RNAs) have emerged as novel
intercellular messengers between animal cells, including pathogens. In infectious diseases …

Differences in the secretory exosomes of Clonorchis sinensis adults at different incubation times

X Zhang, S Duan, X Li, J Ding, L Zuo, B Sun, X Zhang… - Acta Tropica, 2022 - Elsevier
Exosomes are small membrane vesicles of endocytic origin and widely involved in a variety
of physiological and pathological conditions. Exosome-like vesicles (ELVs) have been …

Function of lipid binding proteins of parasitic helminths: still a long road

JF Lombardo, JL Pórfido, MS Sisti, AN Giorello… - Parasitology …, 2022 - Springer
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases
in humans and domestic animals on a global scale. Unable to synthesize de novo their own …

[HTML][HTML] Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro

N Macchiaroli, M Preza, MG Pérez… - PLoS Neglected …, 2021 - journals.plos.org
The neglected zoonotic disease alveolar echinococcosis (AE) is caused by the metacestode
stage of the tapeworm parasite Echinococcus multilocularis. MicroRNAs (miRNAs) are small …