Adult stem cells hold many promises for future clinical applications and regenerative
medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so …

The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …

Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic
leukemia (B-ALL) were investigated using next-generation sequencing and copy number …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

In bone marrow, hematopoiesis is thought to depend on special microenvironments known
as niches that maintain blood cells. However, the identity of niches and interaction of blood …

B-cell development is known to occur in a complex bone-marrow microenvironment but its
functional organization remains unclear. It is thought that bone-marrow stromal cells create …

BACKGROUND/AIMS: Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis.
However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) …

The thymus is the primary site of T-cell lymphopoiesis. However, the precise molecular
interactions that enable the thymus to carry out this function are only recently being …

Leptin, a protein hormone produced by the adipocytes, has long been recognized to
regulate metabolism, neuroendorine and other physiological functions. Early findings of …

Forkhead transcription factors are key participants in development and immune regulation.
Here we demonstrate that absence of the gene encoding the forkhead transcription factor …