The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Improvements in healthcare and nutrition have generated remarkable increases in life
expectancy worldwide. This is one of the greatest achievements of the modern world yet it …

Glycogen metabolism is an important biological process for organisms. In Caenorhabditis
elegans, effect of 6-PPD quinone (6-PPDQ) on glycogen accumulation and underlying …

Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …

Dysregulation of AMPK signaling has been implicated in many human diseases, which
emphasizes the importance of characterizing AMPK regulators. The tumor suppressor …

Receptors of the Notch family mediate cell-cell interactions during animal development, and
aberrations in Notch signaling have been implicated in human disease. Studies in …

Aging represents a triple threat for myocardial infarction (MI). Not only does the incidence of
MI increase with age, but the heart becomes more susceptible to MI induced damage and …