K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

▪ Abstract ATP-sensitive K+ channels (KATP channels) play important roles in many cellular
functions by coupling cell metabolism to electrical activity. By cloning members of the novel …

The subunit stoichiometry of the mammalian K+ channel KVl. l (RCKl) was examined by
linking together the coding sequences of 2-5 K+ channel subunits in a single open reading …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain
is enhanced by the association of two different types of subunits, the membrane-bound, pore …

THE voltage-activated K+, Na+ and Ca2+ channels are responsible for the generation and
propagation of electrical signals in cell membranes. The K+ channels are multimeric …

Measuring electrical activity in large numbers of cells with high spatial and temporal
resolution is a fundamental problem for the study of neural development and information …

Abstract Epilepsy affects more than 0.5% of the world's population and has a large genetic
component. It is due to an electrical hyperexcitability in the central nervous system …

Abstract VOLTAGE-GATED potassium (K+) channels display a wide variety of conductances
and gating properties in vivo 1–3. This diversity can be attributed not only to the presence of …

Recently, de novo mutations in the gene KCNA2, causing either a dominant-negative loss-of-
function or a gain-of-function of the voltage-gated K+ channel Kv1. 2, were described to …