Tumor cells escape the immune surveillance system of the host through a process called
immune tolerance. Immunotherapy targets molecules that serve as checks and balances in …

The inability of the host immune system to control tumor growth appears to result from
dominant mechanisms of immune suppression that prevent the immune system from …

Receptor for advanced glycation end products (RAGE) plays a role in inflammatory
reactions. The soluble form of RAGE (sRAGE) acts as a decoy to inhibit interactions of RAGE …

Kidney transplantation is unquestionably the most advantageous and preferred treatment
when patients with end-stage renal disease are considered. It does have a substantially …

Background: The discovery of indoleamine 2, 3-dioxygenase (IDO) as a modulator for the
maintenance of fetomaternal immuno-privileged state has been heralded as a significant …

Taking advantage of key interactions between sulfoxide and heme cofactor, we used the
sulfoxide as the anchor functional group to develop two series of indoleamine 2, 3 …

Purpose Penetrating keratoplasty has been the mainstay for the treatment of blindness and
is the most common form of tissue transplantation worldwide. Due to significant rates of …

The shortage of donors for organ transplantation and also to treat degenerative diseases
has led to the development of the new field of regenerative medicine. One aim of this field, in …

Idiosyncratic drug reactions are unpredictable adverse reactions. Although most such
adverse reactions appear to be immune mediated, their exact mechanism (s) remain …

BACKGROUND: The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular
enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been …