Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging
ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …
Safety and tolerability of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in oncology
RR Shah, DR Shah - Drug safety, 2019 - Springer
Tyrosine kinase inhibitors (TKIs) that target epidermal growth factor receptor (EGFR) have
dramatically improved progression-free survival in non-small-cell lung cancer (NSCLC) …
dramatically improved progression-free survival in non-small-cell lung cancer (NSCLC) …
Next‐generation pathology practices with mass spectrometry imaging
Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution
of various molecules in biological samples, and it is widely used in pathology‐related …
of various molecules in biological samples, and it is widely used in pathology‐related …
Quantitative mass spectrometry imaging reveals mutation status-independent lack of imatinib in liver metastases of gastrointestinal stromal tumors
D Abu Sammour, C Marsching, A Geisel, K Erich… - Scientific reports, 2019 - nature.com
Mass spectrometry imaging (MSI) is an enabling technology for label-free drug disposition
studies at high spatial resolution in life science-and pharmaceutical research. We present …
studies at high spatial resolution in life science-and pharmaceutical research. We present …
MALDI-MSI analysis of cancer drugs: Significance, advances, and applications
Q He, C Sun, J Liu, Y Pan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …
Spatial mapping of cancer tissues by OMICS technologies
Spatial mapping of heterogeneity in gene expression in cancer tissues can improve our
understanding of cancers and help in the rapid detection of cancers with high accuracy and …
understanding of cancers and help in the rapid detection of cancers with high accuracy and …
Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance
M Jove, J Spencer, M Clench, PM Loadman… - Critical reviews in …, 2019 - Elsevier
Failure of systemic cancer treatment can be, at least in part, due to the drug not being
delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous …
delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous …
Imaging and quantifying drug delivery in skin–part 1: Autoradiography and mass spectrometry imaging
S Grégoire, GS Luengo, P Hallegot, AM Pena… - Advanced Drug Delivery …, 2020 - Elsevier
In this two-part review we present an up-to-date description of different imaging methods
available to map the localization of drugs on skin as a complement of established ex-vivo …
available to map the localization of drugs on skin as a complement of established ex-vivo …
The space dimension at the micro level: mass spectrometry imaging of drugs in tissues
Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …
Comparative study on the efficacy and exposure of molecular target agents in non–small cell lung cancer PDX models with driver genetic alterations
H Jo, S Yagishita, Y Hayashi, S Ryu, M Suzuki… - Molecular Cancer …, 2022 - AACR
Patient-derived xenografts (PDX) can adequately reflect clinical drug efficacy. However, the
methods for evaluating drug efficacy are not fully established. We selected five non–small …
methods for evaluating drug efficacy are not fully established. We selected five non–small …