DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …

In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific
transcriptional programs. Targeted epigenome editing is an emerging technology to …

DNA methylation is an important epigenetic modification that is essential for various
developmental processes through regulating gene expression, genomic imprinting, and …

As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …

Increasingly, the gut microbiome is implicated in the etiology of cancer, not only as an
infectious agent but also by altering exposure to dietary compounds that influence disease …

Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer
genomics and tumor biology. In parallel, information gleaned from these studies on driver …

The PWWP domain of DNMT3 DNA methyltransferases binds to histone H3 tails containing
methylated K36, and this activity is important for heterochromatic targeting. Here, we show …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …