Physiological and pathological roles of lipogenesis

YG Jeon, YY Kim, G Lee, JB Kim - Nature Metabolism, 2023 - nature.com
Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

R Patel, A Santoro, P Hofer, D Tan, M Oberer… - Nature, 2022 - nature.com
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Understanding FAHFAs: From structure to metabolic regulation

K Brejchova, L Balas, V Paluchova, M Brezinova… - Progress in lipid …, 2020 - Elsevier
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …

The human islet: mini-organ with mega-impact

JT Walker, DC Saunders, M Brissova… - Endocrine …, 2021 - academic.oup.com
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources

JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

Lipid remodeling of adipose tissue in metabolic health and disease

YK Cho, S Lee, J Lee, J Doh, JH Park… - … & Molecular Medicine, 2023 - nature.com
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Insulin action in adipocytes, adipose remodeling, and systemic effects

A Santoro, TE McGraw, BB Kahn - Cell metabolism, 2021 - cell.com
On this 100 th anniversary of the discovery of insulin, we recognize the critical role that
adipocytes, which are exquisitely responsive to insulin, have played in determining the …

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

K Brejchova, FPW Radner, L Balas… - Proceedings of the …, 2021 - National Acad Sciences
Branched esters of palmitic acid and hydroxy stearic acid are antiinflammatory and
antidiabetic lipokines that belong to a family of fatty acid (FA) esters of hydroxy fatty acids …

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health

M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …