Neuroinflammation is a major component of central nervous system (CNS) injuries and
neurological diseases, including Alzheimer's disease, multiple sclerosis, neuropathic pain …

Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …

Pain is a physiological response to bodily damage and serves as a warning of potential
threat. Pain can also transform from an acute response to noxious stimuli to a chronic …

The skin is a highly organized tissue composed of multiple layers and cell types that require
coordinated cell to cell communication to maintain tissue homeostasis. In skin cancer, this …

Abstract Pannexin 3 (PANX3) is a member of the pannexin family of single membrane
channel-forming glycoproteins. Originally thought to have a limited localization in cartilage …

The epidermis serves as a protective barrier against external threats and is primarily
composed of keratinocytes, which ultimately form corneocytes. Involucrin, a protein integral …

Cell-to-cell communication through gap junction channels is very important to coordinate the
functions of cells in all multicellular biological tissues. It allows the direct exchange of ions …

The development of mammalian adaptive (ie, B and T cell-mediated) immune responses is
tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from …

The channel-forming glycoprotein PANX3 functions in cutaneous wound healing and
keratinocyte differentiation, but its role in maintaining skin homeostasis through aging is not …

Pannexins (PANX) are a family of three channel-forming membrane glycoproteins
expressed in the skin. Previous studies have focused on the role of PANX1 and PANX3 in …