Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer
M Gu, Y Liu, W Zheng, Z Jing, X Li, W Guo… - Seminars in cancer …, 2024 - Elsevier
Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-
related deaths. Macrophages play a key role in the immune response and the tumour …
related deaths. Macrophages play a key role in the immune response and the tumour …
The brain–body energy conservation model of aging
Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …
Glycolysis, The Sweet Appetite of the Tumour Microenvironment
Z Kooshan, L Cárdenas-Piedra, J Clements, J Batra - Cancer Letters, 2024 - Elsevier
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis
and lactate production, even in the presence of sufficient oxygen-a phenomenon known as …
and lactate production, even in the presence of sufficient oxygen-a phenomenon known as …
Cellular senescence and inflammaging in the bone: pathways, genetics, anti-aging strategies and interventions
M Lawrence, A Goyal, S Pathak… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Advancing age is associated with several age-related diseases (ARDs), with
musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic …
musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic …
METTL3-regulated m6A modification of lncRNA E230001N04Rik is involved in myofibroblast differentiation in arsenic-induced pulmonary fibrosis through promoting …
T Xiao, P Wang, M Wu, C Cheng, Y Yang… - Journal of Hazardous …, 2024 - Elsevier
Arsenic is a toxic agent that causes respiratory damage. Long non-coding RNAs (lncRNAs)
are non-coding transcripts that adsorb specific miRNAs and regulate biological processes of …
are non-coding transcripts that adsorb specific miRNAs and regulate biological processes of …
[HTML][HTML] Therapy-induced cellular senescence: Potentiating tumor elimination or driving cancer resistance and recurrence?
Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its
association with aging and inflammation, its role as a response to deregulated proliferation …
association with aging and inflammation, its role as a response to deregulated proliferation …
Detecting global and local hierarchical structures in cell-cell communication using CrossChat
Cell-cell communication (CCC) occurs across different biological scales, ranging from
interactions between large groups of cells to interactions between individual cells, forming a …
interactions between large groups of cells to interactions between individual cells, forming a …
Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts
Y Chen, X Zheng, Y Wang, C Liu, J Shi, T Liu, S Lin… - Food & Function, 2024 - pubs.rsc.org
Background: Diet quality significantly influences aging processes and age-related health
outcomes. This study aims to explore the association between dietary quality and …
outcomes. This study aims to explore the association between dietary quality and …
Telomere dynamics in human health and disease
DM Baird - Cold Spring Harbor Perspectives in Biology, 2024 - cshperspectives.cshlp.org
Telomere function is critical for genomic stability; in the context of a functional TP53
response, telomere erosion leads to a G 1/S cell-cycle arrest and the induction of replicative …
response, telomere erosion leads to a G 1/S cell-cycle arrest and the induction of replicative …