Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Background and Objectives Randomization, allocation concealment, and blind outcome
assessment have been shown to reduce bias in human studies. Authors from the …

The reliability of experimental findings depends on the rigour of experimental design. Here
we show limited reporting of measures to reduce the risk of bias in a random sample of life …

Bone metastasis, a clinical complication of patients with advanced breast cancer, seriously
reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus …

Neuropathic pain remains an area of considerable unmet clinical need. Research based on
preclinical animal models has failed to deliver truly novel treatment options, questioning the …

Targeting αvβ3 integrin is particularly promising for the treatment of bone metastases by
targeting integrin-rich tumor cells and by inhibiting integrin-involved bone metastases. In this …

The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

As the most common symptomatic reason to seek medical consultation, pain is a complex
experience that has been classified into different categories and stages. In pain processing …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Multiple myeloma patients experience severe bone pain (MMBP) that is undertreated and
poorly understood. In this study, we studied MMBP in an intratibial mouse xenograft model …