Hematopoiesis and mast cell development

D Ribatti, A d'Amati - International Journal of Molecular Sciences, 2023 - mdpi.com
Hematopoietic stem cells (HSCs) are defined based on their capacity to replenish
themselves (self-renewal) and give rise to all mature hematopoietic cell types (multi-lineage …

Landscape of mast cell populations across organs in mice and humans

M Tauber, L Basso, J Martin, L Bostan… - Journal of Experimental …, 2023 - rupress.org
Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …

Human lung mast cells: therapeutic implications in asthma

R Poto, G Criscuolo, G Marone, CE Brightling… - International Journal of …, 2022 - mdpi.com
Mast cells are strategically located in different compartments of the lung in asthmatic
patients. These cells are widely recognized as central effectors and immunomodulators in …

OmicVerse: a framework for bridging and deepening insights across bulk and single-cell sequencing

Z Zeng, Y Ma, L Hu, B Tan, P Liu, Y Wang… - Nature …, 2024 - nature.com
Single-cell sequencing is frequently affected by “omission” due to limitations in sequencing
throughput, yet bulk RNA-seq may contain these ostensibly “omitted” cells. Here, we …

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts

Y Taketomi, T Higashi, K Kano, Y Miki, C Mochizuki… - Immunity, 2024 - cell.com
Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue
microenvironments, although the underlying mechanism is incompletely understood …

Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

Y Chen, CEM Griffiths, S Bulfone-Paus - International Journal of …, 2023 - mdpi.com
The skin is exposed to environmental challenges and contains skin-resident immune cells,
including mast cells (MCs) and CD8 T cells that act as sentinels for pathogens and …

Mast cells in upper and lower airway diseases: sentinels in the front line

G Costanzo, GAML Costanzo, L Del Moro… - International Journal of …, 2023 - mdpi.com
Mast cells (MCs) are fascinating cells of the innate immune system involved not only in
allergic reaction but also in tissue homeostasis, response to infection, wound healing …

Transcriptome profiling and ceRNA network of small extracellular vesicles from resting and degranulated mast cells

L Lin, Y Liang, T Cao, Y Huang, W Li, J Li, J Wang… - …, 2023 - Taylor & Francis
Aim: This study aimed to investigate the transcriptomic characteristics and interactions
between competitive endogenous RNAs (ceRNAs) within small extracellular vesicles (sEVs) …

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

X Zhang, Y Xiao, B Hu, Y Li, S Zhang, J Tian, S Wang… - Bone Research, 2024 - nature.com
Tendon adhesion is a common complication after tendon injury with the development of
accumulated fibrotic tissues without effective anti-fibrotic therapies, resulting in severe …

[HTML][HTML] Endocannabinoid modulation of allergic responses: focus on the control of FcεRI-mediated mast cell activation

RM Osorio-Perez, G Rodríguez-Manzo… - European Journal of …, 2023 - Elsevier
Allergic reactions are highly prevalent pathologies initiated by the production of IgE
antibodies against harmless antigens (allergens) and the activation of the high-affinity IgE …