Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive mitochondrial
oxidant stress. However, its importance as a drug target has not been clarified. To …

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …

Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively
safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury …

Mitochondrial biogenesis (MB) is an adaptive response to maintain metabolic homeostasis
after mitochondrial dysfunction. Induction of MB during APAP hepatotoxicity has not been …

Currently, drug-induced liver injury caused by acetaminophen (APAP) is the second leading
cause of human liver transplantation. The only clinical antidote treatment for APAP-induced …