Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …
treatment protocols based on a single vascular complication are no longer suitable for the …
Peptidomics
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective …
N Tofte, M Lindhardt, K Adamova… - The lancet Diabetes & …, 2020 - thelancet.com
Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …
Biomarkers of diabetic kidney disease
HM Colhoun, ML Marcovecchio - Diabetologia, 2018 - Springer
Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …
Integrated multi-omics approaches to improve classification of chronic kidney disease
S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
Diagnosis and prediction of CKD progression by assessment of urinary peptides
JP Schanstra, P Zürbig, A Alkhalaf… - Journal of the …, 2015 - journals.lww.com
Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or
the presence of significant albuminuria. With the aim of early and improved risk stratification …
the presence of significant albuminuria. With the aim of early and improved risk stratification …
Potential role of serum and urinary biomarkers in diagnosis and prognosis of diabetic nephropathy
CG Campion, O Sanchez-Ferras… - Canadian journal of …, 2017 - journals.sagepub.com
Purpose of review: Diabetic nephropathy (DN) is a progressive kidney disease caused by
alterations in kidney architecture and function, and constitutes one of the leading causes of …
alterations in kidney architecture and function, and constitutes one of the leading causes of …
Precision prognostics for the development of complications in diabetes
C Schiborn, MB Schulze - Diabetologia, 2022 - Springer
Individuals with diabetes face higher risks for macro-and microvascular complications than
their non-diabetic counterparts. The concept of precision medicine in diabetes aims to …
their non-diabetic counterparts. The concept of precision medicine in diabetes aims to …
Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
A urinary proteome-based classifier for the early detection of decline in glomerular filtration
C Pontillo, L Jacobs, JA Staessen… - Nephrology Dialysis …, 2017 - academic.oup.com
Background. Chronic kidney disease (CKD) progression is currently assessed by a decline
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …