The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …

The hammerhead, hairpin, hepatitis delta virus (HDV), Varkud Satellite (VS), and glmS
ribozymes catalyze sequence-specific intramolecular cleavage of RNA. They range between …

We assembled a DNA clone containing the 11,161-nt sequence of the prototype
rhabdovirus, vesicular stomatitis virus (VSV), such that it could be transcribed by the …

The generation of infectious rabies virus (RV), a non‐segmented negative‐stranded RNA
virus of the Rhabdoviridae family, entirely from cloned cDNA is described. Simultaneous …

The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known
to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide …

The addition of the hepatitis delta virus genomic ribozyme to the 3'end sequence of a Sendai
virus defective interfering RNA (DI-H4) allowed the reproducible and efficient replication of …

To study the mechanisms underlying the high pathogenicity of Ebola virus, we have
established a system that allows the recovery of infectious virus from cloned cDNA and thus …

ABSTRACT M2-1 protein of human respiratory syncytial virus (RSV) is a transcription
antitermination factor that is important for the efficient synthesis of full-length mRNAs as well …

Ribozymes enhance chemical reaction rates using many of the same catalytic strategies as
protein enzymes. In the hepatitis delta virus (HDV) ribozyme, site-specific self-cleavage of …

A reverse genetics system for negative-strand RNA viruses was first successfully developed
for influenza viruses. This technology involved the transfection of in vitro-reconstituted …