Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations

S Moradi, H Mahdizadeh, T Šarić, J Kim… - Stem cell research & …, 2019 - Springer
Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …

Engineered reproductive tissues

ES Gargus, HB Rogers, KE McKinnon… - Nature biomedical …, 2020 - nature.com
Engineered male and female biomimetic reproductive tissues are being developed as
autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell …

Cloning for the Twenty-First Century and Its Place in Endangered Species Conservation

VB Cowl, P Comizzoli, R Appeltant… - Annual Review of …, 2024 - annualreviews.org
Cloning as it relates to the animal kingdom generally refers to the production of genetically
identical individuals. Because cloning is increasingly the subject of renewed attention as a …

Genetic and epigenetic factors which modulate differentiation propensity in human pluripotent stem cells

A Keller, D Dziedzicka, F Zambelli… - Human …, 2018 - academic.oup.com
BACKGROUND Human pluripotent stem cell (hPSC) lines are known to have a bias in their
differentiation. This gives individual cell lines a propensity to preferentially differentiate …

Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship

G Cavaliere, C Palacios-González - Journal of medical ethics, 2018 - jme.bmj.com
In this paper, we argue that lesbian couples who wish to have children who are genetically
related to both of them should be allowed access to mitochondrial replacement techniques …

Getting what you desire: the normative significance of genetic relatedness in parent–child relationships

S Segers, G Pennings, H Mertes - Medicine, health care and philosophy, 2019 - Springer
People who are involuntarily childless need to use assisted reproductive technologies if they
want to have a genetically related child. Yet, from an ethical point of view it is unclear to what …

Novel approaches in addressing ovarian insufficiency in 2019: Are we there yet?

K Sfakianoudis, A Rapani, S Grigoriadis… - Cell …, 2020 - journals.sagepub.com
Ovarian insufficiency is described as a multifaceted issue typically encountered in the field of
assisted reproduction. The three main identified diagnoses of ovarian insufficiency include …

Drawing the line on in vitro gametogenesis

L Notini, C Gyngell, J Savulescu - Bioethics, 2020 - Wiley Online Library
In vitro gametogenesis (IVG) might offer numerous research and clinical benefits. Some
potential clinical applications of IVG, such as allowing opposite‐sex couples experiencing …

Rapid differentiation of human dental pulp stem cells to neuron-like cells by high K+ stimulation

Y Kogo, C Seto, Y Totani, M Mochizuki… - Biophysics and …, 2020 - jstage.jst.go.jp
As human-origin cells, human dental pulp stem cells (hDPSCs) are thought to be potentially
useful for biological and medical experiments. They are easily obtained from lost primary …

[图书][B] The philosopher's guide to parenthood: storks, surrogates, and stereotypes

T Baron - 2023 - books.google.com
Our understanding of what it means to be a parent in any given context is shaped by our
biological, social, legal, and moral concepts of parenthood. These are themselves subject to …