The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …

Although oxidative phosphorylation is best known for producing ATP, it also yields reactive
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …

Mucinases of human gut bacteria cleave peptide bonds in mucins strictly depending on the
presence of neighboring O-glycans. The Akkermansia muciniphila AM0627 mucinase …

Increasing sophistication in molecular-replacement (MR) software and the rapid expansion
of the PDB in recent years have allowed the technique to become the dominant method for …

Structures of two globular proteins were determined ab initio using microcrystal electron
diffraction (MicroED) data that were collected on a direct electron detector in counting mode …

X-Seed is a native Microsoft Windows program with three primary functions:(i) to serve as a
graphical user interface to the SHELX suite of programs,(ii) to facilitate exploration of crystal …

The meiotic chromosome axis plays key roles in meiotic chromosome organization and
recombination, yet the underlying protein components of this structure are highly diverged …

Assisted by an MS/MS-based molecular networking guided strategy, six undescribed
germacrane-type sesquiterpene lactones, namely scaberxones AF, along with a known …

The electron-conducting circuitry of life represents an as-yet untapped resource of exquisite,
nanoscale biomolecular engineering. Here, we report the characterization and structure of a …

The anaerobic oxidation of alkanes is a microbial process that mitigates the flux of
hydrocarbon seeps into the oceans. In marine archaea, the process depends on sulphate …