Furin is an important mammalian proprotein convertase that catalyzes the proteolytic
maturation of a variety of prohormones and proproteins in the secretory pathway. In the …

Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles
in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the …

It is crucial to understand the molecular mechanisms involved in epileptogenesis. This study
aims to investigate the role of lncRNA NEAT1, miR-129-5p and Notch signaling pathway in …

The Notch signaling pathway is an evolutionarily conserved pathway that modulates normal
biological processes involved in cellular differentiation, apoptosis, and stem cell self …

The glutamate transporter GLT-1 is critical for the maintenance of low interstitial glutamate
concentrations. Loss of GLT-1 is commonly observed in neurological disorders, including …

This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a)
in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model …

The inflammatory response mediated by microglia in the central nervous system is closely
related to epilepsy. Notch signaling plays an important role in the microglial activation during …

Epilepsy is a neurological disorder that affects almost 70 million people worldwide of all
socioeconomic groups. The currently available medications aim to restore the balance …

Emerging evidence suggests that hypoxia-inducible factors (specifically, HIF-1α) and Notch
signaling are involved in epileptogenesis and that cross-coupling exists between HIF-1α …

Dysfunction in glutamate homeostasis contributes to the pathology of depression-like
behavior. Using a chronic restraint stress (CRS) model of depression in C57BL/6 mice, we …