Propofol is an intravenous hypnotic drug that is used for induction and maintenance of
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …

Predicting drug exposures using population pharmacokinetic models through Bayesian
forecasting software can improve individual pharmacokinetic/pharmacodynamic target …

Background Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-
controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a …

BACKGROUND: Pharmacokinetic (PK) models are used to predict drug concentrations for
infusion regimens for intraoperative displays and to calculate infusion rates in target …

Purpose The basis of high intersubject variability of propofol metabolism is unclear.
Therefore, we examined the influence of genetic polymorphisms of the key metabolizing …

This review discusses the ways in which anaesthetists can optimize anaesthetic–analgesic
drug administration by utilizing pharmacokinetic and pharmacodynamic information. We …

Breath analysis not only holds great potential for the development of new non-invasive
diagnostic methods, but also for the identification and follow up of drug levels in breath. This …

Efficiently finding covariate model structures that minimize the need for random effects to
describe pharmacological data is challenging. The standard approach focuses on …

Background To study propofol pharmacodynamics in a clinical setting a pharmacokinetic
model must be used to predict drug plasma concentrations. Some investigators use a …

Background The performance of eight currently available paediatric propofol
pharmacokinetic models in target-controlled infusions (TCIs) was assessed, in healthy …