Background Closed-loop artificial pancreas systems have been in development for several
years, including assessment in numerous varied outpatient clinical trials. We aimed to …

This paper provides an overview of recent developments in big data in the context of
biomedical and health informatics. It outlines the key characteristics of big data and how …

Background: The safety and effectiveness of the in-home use of a hybrid closed-loop (HCL)
system that automatically increases, decreases, and suspends insulin delivery in response …

Background The feasibility, safety, and efficacy of prolonged use of an artificial beta cell
(closed-loop insulin-delivery system) in the home setting have not been established …

Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical
aspects of artificial pancreas (AP) development are described. In the preceding Bench …

The successful assembly of large supramolecular structures infers a delicate balance
between reversible noncovalent interactions which are capable of undergoing correction …

Background In patients with type 1 diabetes who are not pregnant, closed-loop (automated)
insulin delivery can provide better glycemic control than sensor-augmented pump therapy …

Abstract Machine learning has become a popular tool for learning models of complex
dynamics from biomedical data. In Type 1 Diabetes (T1D) management, these models are …

Background An artificial pancreas (AP) that can be worn at home from dinner to waking up in
the morning might be safe and efficient for first routine use in patients with type 1 diabetes …