Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Since their discovery, the study of maternal mRNA s has led to the identification of
mechanisms underlying their spatiotemporal regulation within the context of oogenesis and …

A fundamental question in developmental biology is how the early embryo establishes the
spatial coordinate system that is later important for the organization of the embryonic body …

Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network
support essential developmental processes and their disruption lead to neurodevelopmental …

The source of symmetry breaking in vertebrate oocytes is unknown. Animal—vegetal oocyte
polarity is established by the Balbiani body (Bb), a conserved structure found in all animals …

A mechanistic dissection of early oocyte differentiation in vertebrates is key to advancing our
knowledge of germline development, reproductive biology, the regulation of meiosis, and all …

Over the past decades, studies using zebrafish have significantly advanced our
understanding of the cellular basis for development and human diseases. Zebrafish have …

Gastrulation entails specification and formation of three embryonic germ layers—ectoderm,
mesoderm and endoderm—thereby establishing the basis for the future body plan. In …

Maintenance and differentiation of germline stem and progenitor cells (GSPCs) is important
for sexual reproduction. Here, the authors identify zebrafish pld6 as a novel germline …

In many animals, the germline is specified by maternal RNA-granules termed germ plasm.
The correct localization of germ plasm during embryogenesis is therefore crucial for the …