The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …

SNARE-complexes drive the fusion of membrane-bound vesicles with target membranes or
with each other (homotypic fusion). The SNARE-proteins are subdivided into Q a, Q b, Q c …

Many biological functions depend critically upon fine details of tissue molecular architecture
that have resisted exploration by existing imaging techniques. This is particularly true for …

The maturation of young neurons is regulated by complex mechanisms and dysregulation of
this process is frequently found in neurodevepmental disorders. MicroRNAs have been …

Summary Neuregulin-1 (NRG1), a regulator of neural development, has been shown to
regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is …

Experimental advances in the study of neuroglia signaling have been greatly accelerated by
the generation of transgenic mouse models. In particular, an elegant manipulation that …

J. Neurochem.(2010) 113, 1577–1588. Abstract Decreased cognitive performance reduces
independence and quality of life for aging individuals. Healthy brain aging does not involve …

BACKGROUND: Structural and functional neuroimaging studies suggest abnormal activity in
the striatum of patients with the fragile X syndrome (FXS), the most common form of inherited …

The SNAP receptor (SNARE) complex, consisting of synaptosome-associated protein of 25
kDa (SNAP-25), synaptobrevin-2, and syntaxin-1, is involved in synaptic vesicles exocytosis …

Synaptic dysfunction triggers neuronal damage in experimental autoimmune
encephalomyelitis (EAE), a model of multiple sclerosis (MS). While excessive glutamate …