Homologous Recombination Deficiency Detection Algorithms: A Systematic Review
LR Mark, SK Terp, HB Krarup, M Thomassen… - Cancers, 2023 - mdpi.com
Simple Summary Homologous recombination deficiency (HRD) originates from genomic
mutations or alterations in the homologous recombination repair pathway. Various …
mutations or alterations in the homologous recombination repair pathway. Various …
[HTML][HTML] Comprehensive analysis of lncRNA expression profiles reveals a novel lncRNA signature to discriminate nonequivalent outcomes in patients with ovarian …
There is growing evidence of dysregulated long non-coding RNAs (lncRNAs) serving as
potential biomarkers for cancer prognosis. However, systematic efforts of searching for an …
potential biomarkers for cancer prognosis. However, systematic efforts of searching for an …
Immuno-genomic characterisation of high-grade serous ovarian cancer reveals immune evasion mechanisms and identifies an immunological subtype with a …
Background Immunotherapy has revolutionised the field of cancer therapy and immunology,
but has demonstrated limited therapeutic efficacy in high-grade serous ovarian cancer …
but has demonstrated limited therapeutic efficacy in high-grade serous ovarian cancer …
The RECAP test rapidly and reliably identifies homologous recombination-deficient ovarian carcinomas
LM van Wijk, S Vermeulen, M Meijers, MF van Diest… - Cancers, 2020 - mdpi.com
Simple Summary The sensitivity to PARP inhibitors (PARPi) is related to tumor-specific
defects in homologous recombination (HR) and extends beyond BRCA1/2-related …
defects in homologous recombination (HR) and extends beyond BRCA1/2-related …
Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma
Purpose: The abundance and effects of structural variation at BRCA1/2 in tumors are not
well understood. In particular, the impact of these events on homologous recombination …
well understood. In particular, the impact of these events on homologous recombination …
Multi-omics deep-learning prediction of homologous recombination deficiency-like phenotype improved risk stratification and guided therapeutic decisions in …
Y Zhang, C Yan, Z Yang, M Zhou… - IEEE journal of …, 2023 - ieeexplore.ieee.org
Homologous recombination deficiency (HRD) is a well-recognized important biomarker in
determining the clinical benefits of platinum-based chemotherapy and PARP inhibitor …
determining the clinical benefits of platinum-based chemotherapy and PARP inhibitor …
[HTML][HTML] Expression profiles analysis reveals an integrated miRNA-lncRNA signature to predict survival in ovarian cancer patients with wild-type BRCA1/2
L Guo, Y Peng, Y Meng, Y Liu, S Yang, H Jin, Q Li - Oncotarget, 2017 - ncbi.nlm.nih.gov
Emerging evidence shows that dysregulated expression of microRNAs (miRNAs) and long
non-coding RNAs (lncRNAs) were closely linked with disease progression, including …
non-coding RNAs (lncRNAs) were closely linked with disease progression, including …
[PDF][PDF] Exploring public cancer gene expression signatures across bulk, single-cell and spatial transcriptomics data with signifinder Bioconductor package
S Pirrotta, L Masatti, A Bortolato, A Corrà… - NAR Genomics and …, 2024 - academic.oup.com
Understanding cancer mechanisms, defining subtypes, predicting prognosis and assessing
therapy efficacy are crucial aspects of cancer research. Gene-expression signatures derived …
therapy efficacy are crucial aspects of cancer research. Gene-expression signatures derived …
Large-scale integrated analysis of ovarian cancer tumors and cell lines identifies an individualized gene expression signature for predicting response to platinum …
Heterogeneity in chemotherapeutic response is directly associated with prognosis and
disease recurrence in patients with ovarian cancer (OvCa). Despite the significant clinical …
disease recurrence in patients with ovarian cancer (OvCa). Despite the significant clinical …
The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents
Abstract miRNAs, a class of short but stable noncoding RNA molecules, have been revealed
to play important roles in the DNA damage response (DDR). However, their functions in …
to play important roles in the DNA damage response (DDR). However, their functions in …