Thiol-based redox metabolism of protozoan parasites
S Müller, E Liebau, RD Walter, RL Krauth-Siegel - Trends in parasitology, 2003 - cell.com
The review considers redox enzymes of Plasmodium spp., Trypanosomatida, Trichomonas,
Entamoeba and Giardia, with special emphasis on their potential use as targets for drug …
Entamoeba and Giardia, with special emphasis on their potential use as targets for drug …
Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by “amitochondriate” protozoan parasites
The “amitochondriate” protozoan parasites of humans Entamoeba histolytica, Giardia
intestinalis, and Trichomonas vaginalis share many biochemical features, eg, energy and …
intestinalis, and Trichomonas vaginalis share many biochemical features, eg, energy and …
Structure and content of the Entamoeba histolytica genome
CG Clark, UCM Alsmark, M Tazreiter… - Advances in …, 2007 - Elsevier
The intestinal parasite Entamoeba histolytica is one of the first protists for which a draft
genome sequence has been published. Although the genome is still incomplete, it is …
genome sequence has been published. Although the genome is still incomplete, it is …
Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
F Mi-Ichi, MA Yousuf… - Proceedings of the …, 2009 - National Acad Sciences
Hydrogenosomes and mitosomes are mitochondrion-related organelles in anaerobic/
microaerophilic eukaryotes with highly reduced and divergent functions. The full diversity of …
microaerophilic eukaryotes with highly reduced and divergent functions. The full diversity of …
A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba …
K Nakada-Tsukui, Y Saito-Nakano, V Ali… - Molecular biology of …, 2005 - Am Soc Cell Biol
Vesicular trafficking plays an important role in a virulence mechanism of the enteric
protozoan parasite Entamoeba histolytica as secreted and lysosomal cysteine protease (CP) …
protozoan parasite Entamoeba histolytica as secreted and lysosomal cysteine protease (CP) …
Identification and characterization of two isoenzymes of methionine γ-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an …
M Tokoro, T Asai, S Kobayashi, T Takeuchi… - Journal of Biological …, 2003 - ASBMB
To better understand the metabolism of sulfur-containing amino acids, which likely plays a
key role in a variety of cell functions, in Entamoeba histolytica, we searched the genome …
key role in a variety of cell functions, in Entamoeba histolytica, we searched the genome …
Rab5-associated vacuoles play a unique role in phagocytosis of the enteric protozoan parasite Entamoeba histolytica
Y Saito-Nakano, T Yasuda, K Nakada-Tsukui… - Journal of Biological …, 2004 - ASBMB
In mammals, Rab5 and Rab7 play a specific and coordinated role in a sequential process
during phagosome maturation. Here, we report that Rab5 and Rab7 in the enteric protozoan …
during phagosome maturation. Here, we report that Rab5 and Rab7 in the enteric protozoan …
Low-molecular-mass antioxidants in parasites
RL Krauth-Siegel, AE Leroux - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, trypanosoma cruzi: Isolation and molecular characterization …
T Nozaki, Y Shigeta, Y Saito-Nakano, M Imada… - Journal of Biological …, 2001 - ASBMB
Sulfur-containing amino acids play an important role in a variety of cellular functions such as
protein synthesis, methylation, and polyamine and glutathione synthesis. We cloned and …
protein synthesis, methylation, and polyamine and glutathione synthesis. We cloned and …
Sulfur-containing amino acid metabolism in parasitic protozoa
Sulfur-containing amino acids play indispensable roles in a wide variety of biological
activities including protein synthesis, methylation, and biosynthesis of polyamines and …
activities including protein synthesis, methylation, and biosynthesis of polyamines and …