Actin is one of the most abundant proteins in any eukaryotic cell and an indispensable
component of the cytoskeleton. In mammalian organisms, six highly conserved actin …

Defensins, as a prominent family of antimicrobial peptides (AMP), are major effectors of the
innate immunity with a broad range of immune modulatory and antimicrobial activities. In …

Due to its essential role in cellular processes, actin is a common target for bacterial toxins.
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …

Many pathogens manipulate host cell cAMP signaling pathways to promote their survival
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …

Bacteria often coordinate virulence factors to fine‐tune the host response during infection.
These coordinated events can include toxins counteracting or amplifying effects of another …

Delivery of bacterial toxins to host cells is hindered by host protective barriers. This
obstruction dictates a remarkable efficiency of toxins, a single copy of which may kill a host …

The application of proteinaceous toxins for cell ablation is limited by their high on-and off-
target toxicity, severe side effects, and a narrow therapeutic window. The selectivity of …

Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated
pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 …

Actin is an essential element of both innate and adaptive immune systems and can aid in
motility and translocation of bacterial pathogens, making it an attractive target for bacterial …

Klebsiella pneumoniae is an opportunistic pathogen, which concerns public health systems
worldwide, as multiple antibiotic‐resistant strains are frequent. One of its pathogenicity …