Actin: structure, function, dynamics, and interactions with bacterial toxins
S Kühn, HG Mannherz - The actin cytoskeleton and bacterial infection, 2017 - Springer
Actin is one of the most abundant proteins in any eukaryotic cell and an indispensable
component of the cytoskeleton. In mammalian organisms, six highly conserved actin …
component of the cytoskeleton. In mammalian organisms, six highly conserved actin …
Targeting and inactivation of bacterial toxins by human defensins
Defensins, as a prominent family of antimicrobial peptides (AMP), are major effectors of the
innate immunity with a broad range of immune modulatory and antimicrobial activities. In …
innate immunity with a broad range of immune modulatory and antimicrobial activities. In …
Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity
S Dong, W Zheng, N Pinkerton, J Hansen… - International journal of …, 2022 - mdpi.com
Due to its essential role in cellular processes, actin is a common target for bacterial toxins.
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …
Bacterial nucleotidyl Cyclases activated by calmodulin or actin in host cells: enzyme specificities and cytotoxicity mechanisms identified to date
M Teixeira-Nunes, P Retailleau, M Comisso… - International Journal of …, 2022 - mdpi.com
Many pathogens manipulate host cell cAMP signaling pathways to promote their survival
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …
Coordinated delivery and function of bacterial MARTX toxin effectors
PJ Woida, KJF Satchell - Molecular microbiology, 2018 - Wiley Online Library
Bacteria often coordinate virulence factors to fine‐tune the host response during infection.
These coordinated events can include toxins counteracting or amplifying effects of another …
These coordinated events can include toxins counteracting or amplifying effects of another …
Actin cross-linking toxin is a universal inhibitor of tandem-organized and oligomeric G-actin binding proteins
E Kudryashova, DB Heisler, B Williams, AJ Harker… - Current Biology, 2018 - cell.com
Delivery of bacterial toxins to host cells is hindered by host protective barriers. This
obstruction dictates a remarkable efficiency of toxins, a single copy of which may kill a host …
obstruction dictates a remarkable efficiency of toxins, a single copy of which may kill a host …
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts
The application of proteinaceous toxins for cell ablation is limited by their high on-and off-
target toxicity, severe side effects, and a narrow therapeutic window. The selectivity of …
target toxicity, severe side effects, and a narrow therapeutic window. The selectivity of …
Presence of actin binding motif in VgrG-1 toxin of Vibrio cholerae reveals the molecular mechanism of actin cross-linking
Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated
pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 …
pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 …
Rounding Out the Understanding of ACD Toxicity with the Discovery of Cyclic Forms of Actin Oligomers
H Smith, N Pinkerton, DB Heisler… - International journal of …, 2021 - mdpi.com
Actin is an essential element of both innate and adaptive immune systems and can aid in
motility and translocation of bacterial pathogens, making it an attractive target for bacterial …
motility and translocation of bacterial pathogens, making it an attractive target for bacterial …
The C‐terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments
T do Nascimento Soares… - Proteins: Structure …, 2022 - Wiley Online Library
Klebsiella pneumoniae is an opportunistic pathogen, which concerns public health systems
worldwide, as multiple antibiotic‐resistant strains are frequent. One of its pathogenicity …
worldwide, as multiple antibiotic‐resistant strains are frequent. One of its pathogenicity …