The generation of oxygen free radicals is known to be involved in the development of the
systemic inflammatory response syndrome. In addition to their actions as noxious mediators …

The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and
septic shock have been the subject of investigations for nearly half a century. Controversies …

Sepsis is the leading cause of death in medical intensive care units. In most fatal cases of
sepsis the patient experiences an insidious, progressive decline in vital organ function, ie …

Patients recovering from sepsis have higher rates of CNS morbidities associated with long-
lasting impairment of cognitive functions, including neurodegenerative diseases. However …

Objective Oxidative stress plays an important role in the development of multiple organ
failure and septic shock. Here we have evaluated the effects of a combination of antioxidants …

Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced
mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 …

Background Sepsis-associated encephalopathy (SAE) is an early and common feature of
severe infections. Oxidative stress is one of the mechanisms associated with the …

Purpose Globally, sepsis, which is a major health issue resulting from severe infection-
induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for …

During the development of sepsis, the complication in central nervous system (CNS),
appearing early and frequently relative to other systems, can obviously increase the …

Sepsis is the leading cause of death in medical intensive care units. Though progress has
been made in the early treatment of sepsis associated with hemodynamic collapse (septic …