Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …

Chromosome segregation errors during cell divisions generate aneuploidies and
micronuclei, which can undergo extensive chromosomal rearrangements such as …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

Micronuclei (MN) and other nuclear anomalies such as nucleoplasmic bridges (NPBs) and
nuclear buds (NBUDs) are biomarkers of genotoxic events and chromosomal instability …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …

Kinesins are a family of molecular motors that travel unidirectionally along microtubule
tracks to fulfil their many roles in intracellular transport or cell division. Over the past few …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …

The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by clonal
proliferation of plasma cells and a heterogenous genomic landscape. Copy number and …