The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …

Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the
treatment of cancer. For more than two decades, the IRT prodrug has largely contributed to …

Irinotecan has been used in the treatment of various malignancies for many years. Still, the
knowledge regarding this drug is expanding. The pharmacogenetics of the drug is the …

Irinotecan is a topoisomerase inhibitor, widely used in treatment of malignancies including
pancreatic ductal adenocarcinoma (PDAC) as part of the FOLFIRINOX regimen prescribed …

Efferocytosis of apoptotic cancer cells by tumor-associated macrophages or other
phagocytes is reported to promote tumor immunosuppression by preventing them from …

The incidence of brain metastases is increasing as cancer therapies improve and patients
live longer, providing new challenges to the multidisciplinary teams that care for these …

Recently, artificial intelligence applications in magnetic resonance imaging have been
applied in several clinical studies. The analysis of brain tumors without human intervention …

Spread of cancer to the brain remains an unmet clinical need in spite of the increasing
number of cases among patients with lung, breast cancer, and melanoma most notably …

In women, breast cancer is the most common cancer diagnosis and second most common
cause of cancer death. More than half of breast cancer patients will develop metastases to …

The incidence of brain metastases has increased in the last 10 years. However, the survival
of patients with brain metastases remains poor and challenging in daily practice in medical …