Lipids and lipid derivatives for RNA delivery
Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics
Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global
health burden affecting millions of people, with contemporary treatments offering limited …
health burden affecting millions of people, with contemporary treatments offering limited …
Role of lipid-based and polymer-based non-viral vectors in nucleic acid delivery for next-generation gene therapy
The field of gene therapy has experienced an insurgence of attention for its widespread
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
RNA-based therapies: A cog in the wheel of lung cancer defense
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
Potential and applications of nanocarriers for efficient delivery of biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly
increased because of their obvious advantages over conventional small-molecule drug …
increased because of their obvious advantages over conventional small-molecule drug …
RGD peptide‐based target drug delivery of doxorubicin nanomedicine
ABSTRACT Preclinical Research Doxorubicin (DOX) is commonly used for the treatment of
breast cancer and lymphoma. However, its clinical use has been severely limited due to …
breast cancer and lymphoma. However, its clinical use has been severely limited due to …
High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …
editing and regulating protein translation has led to the effective treatment of various …
Non-coding RNA-directed therapeutics in lung cancer: delivery technologies and clinical applications
AAH Abdellatif, G Scagnetti, MA Younis… - Colloids and Surfaces B …, 2023 - Elsevier
Lung cancer is one of the most aggressive and deadliest health threats. There has been an
increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of …
increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of …
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement
ABSTRACT Introduction Ionizable lipid nanoparticles (LNPs) have been proven to have high
encapsulation, cellular uptake, and effective endosomal escape and are therefore promising …
encapsulation, cellular uptake, and effective endosomal escape and are therefore promising …
Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment
A Szymanowska, C Rodriguez-Aguayo… - Non-coding RNA, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …
growth regulation. They are key regulators of important cellular pathways in the tumor …