Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, although …

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …

Protecting axons from degeneration represents a major unmet need in the treatment of
myelin disorders and especially the currently untreatable secondary progressive stages of …

Remyelination is the phenomenon by which new myelin sheaths are generated around
axons in the adult central nervous system (CNS). This follows the pathological loss of myelin …

The concept of the oligodendrocyte lineage as simply a source of myelinating cells in the
vertebrate CNS is undergoing radical revision. Elucidation of the origins of oligodendrocytes …

Diffuse white matter injury (DWMI) caused by hypoxia is associated with permanent
neurodevelopmental disabilities in preterm infants. The cellular and molecular mechanisms …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, while this …

Oligodencrocytes (OLs) are the main glial cells of the central nervous system involved in
myelination of axons. In multiple sclerosis (MS), there is an imbalance between …

Neural tissue regeneration following traumatic injuries is often subpar. As a result, the field
of neural tissue engineering has evolved to find therapeutic interventions and has seen …