[HTML][HTML] Phage delivered CRISPR-Cas system to combat multidrug-resistant pathogens in gut microbiome
The Host-microbiome interactions that exist inside the gut microbiota operate in a synergistic
and abnormal manner. Additionally, the normal homeostasis and functioning of gut …
and abnormal manner. Additionally, the normal homeostasis and functioning of gut …
In silico methods for identification of potential therapeutic targets
X Zhang, F Wu, N Yang, X Zhan, J Liao, S Mai… - Interdisciplinary …, 2022 - Springer
At the initial stage of drug discovery, identifying novel targets with maximal efficacy and
minimal side effects can improve the success rate and portfolio value of drug discovery …
minimal side effects can improve the success rate and portfolio value of drug discovery …
CELLO2GO: a web server for protein subCELlular LOcalization prediction with functional gene ontology annotation
CELLO2GO (http://cello. life. nctu. edu. tw/cello2go/) is a publicly available, web-based
system for screening various properties of a targeted protein and its subcellular localization …
system for screening various properties of a targeted protein and its subcellular localization …
Network-Based Metabolism-Centered Screening of Potential Drug Targets in Klebsiella pneumoniae at Genome Scale
Klebsiella pneumoniae is an opportunistic bacterial pathogen leading to life-threatening
nosocomial infections. Emergence of highly resistant strains poses a major challenge in the …
nosocomial infections. Emergence of highly resistant strains poses a major challenge in the …
A different microbiome gene repertoire in the airways of cystic fibrosis patients with severe lung disease
In recent years, next-generation sequencing (NGS) was employed to decipher the structure
and composition of the microbiota of the airways in cystic fibrosis (CF) patients. However …
and composition of the microbiota of the airways in cystic fibrosis (CF) patients. However …
Screening and characterization of hypothetical proteins of Plasmodium falciparum as novel vaccine candidates in the fight against malaria using reverse vaccinology
Background Plasmodium falciparum is the most deadly and leading cause of morbidity and
mortality in Africa. About 90% of all malaria deaths in the world today occur in Sub-Saharan …
mortality in Africa. About 90% of all malaria deaths in the world today occur in Sub-Saharan …
Pangenome Analysis of Mycobacterium tuberculosis Reveals Core-Drug Targets and Screening of Promising Lead Compounds for Drug Discovery
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is one of the leading
causes of human deaths globally according to the WHO TB 2019 report. The continuous rise …
causes of human deaths globally according to the WHO TB 2019 report. The continuous rise …
MurB as a target in an alternative approach to tackle the Vibrio cholerae resistance using molecular docking and simulation study
A Ragunathan, K Malathi… - Journal of Cellular …, 2018 - Wiley Online Library
Cholera is a serious threat to a large population in the under developed countries. Though
oral rehydration therapy is the preferred choice of treatment, the use of antibiotics could …
oral rehydration therapy is the preferred choice of treatment, the use of antibiotics could …
Subtractive genomics, molecular docking and molecular dynamics simulation revealed LpxC as a potential drug target against multi-drug resistant Klebsiella …
The emergence and dissemination of pan drug resistant clones of Klebsiella pneumoniae
are great threat to public health. In this regard new therapeutic targets must be highlighted to …
are great threat to public health. In this regard new therapeutic targets must be highlighted to …
[HTML][HTML] Phage-tail-like bacteriocins as a biomedical platform to counter anti-microbial resistant pathogens
Abstract Phage Tail Like bacteriocins (PTLBs) has been an area of interest in the last couple
of years owing to their varied application against multi-drug resistant (MDR), anti-microbial …
of years owing to their varied application against multi-drug resistant (MDR), anti-microbial …