The histone variant H2A. Z in gene regulation

BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

SIRT1 in the brain—connections with aging-associated disorders and lifespan

F Ng, L Wijaya, BL Tang - Frontiers in cellular neuroscience, 2015 - frontiersin.org
The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone
deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the …

Histone H2A. Z subunit exchange controls consolidation of recent and remote memory

IB Zovkic, BS Paulukaitis, JJ Day, DM Etikala… - Nature, 2014 - nature.com
Memory formation is a multi-stage process that initially requires cellular consolidation in the
hippocampus, after which memories are downloaded to the cortex for maintenance, in a …

DNA methylation and histone modifications as epigenetic regulation in prostate cancer

M Nowacka-Zawisza, E Wiśnik - Oncology reports, 2017 - spandidos-publications.com
Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung
cancer and the third leading cause of cancer-related mortality after lung and colon cancer …

Sirtuin‐dependent epigenetic regulation in the maintenance of genome integrity

L Bosch‐Presegué, A Vaquero - The FEBS journal, 2015 - Wiley Online Library
Sirtuins are a family of deacetylases that target histone and non‐histone proteins and
require NAD+ as an enzymatic cofactor for their enzymatic activity. This requirement confers …

[PDF][PDF] Tumor‐infiltrating, interleukin‐33–producing effector‐memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

SM Brunner, C Rubner, R Kesselring, M Martin… - …, 2015 - Wiley Online Library
Interleukin‐33 (IL‐33), a cytokine with pleiotropic functions, is elevated in serum of patients
with hepatocellular carcinoma (HCC). This study investigated the effects of local IL‐33 …

Histone variants: nuclear function and disease

LM Zink, SB Hake - Current opinion in genetics & development, 2016 - Elsevier
Histone variants have emerged as important contributors to the regulation of chromatin
structure and therefore of almost all DNA-based processes. Hence, these specialized …

Epigenetic modulators as therapeutic targets in prostate cancer

I Graça, E Pereira-Silva, R Henrique, G Packham… - Clinical …, 2016 - Springer
Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …

[HTML][HTML] Oncogenic potential of histone-variant H2A. Z. 1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer

HD Yang, PJ Kim, JW Eun, Q Shen, HS Kim, WC Shin… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract H2A. Z is a highly conserved H2A variant, and two distinct H2A. Z isoforms, H2A. Z.
1 and H2A. Z. 2, have been identified as products of two non-allelic genes, H2AFZ and …

Integrated analysis of H2A. Z isoforms function reveals a complex interplay in gene regulation

A Lamaa, J Humbert, M Aguirrebengoa, X Cheng… - Elife, 2020 - elifesciences.org
The H2A. Z histone variant plays major roles in the control of gene expression. In human,
H2A. Z is encoded by two genes expressing two isoforms, H2A. Z. 1 and H2A. Z. 2 differing …