The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. There is no
test for its definitive diagnosis in routine clinical practice. Although phase III clinical trials …

In this study, we report the results of a comprehensive phenotyping of the retina of the App
NL-GF mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these …

New studies show that the retina also undergoes pathological changes during the
development of Alzheimer's disease (AD). While transgenic mouse models used in these …

Age-related macular degeneration (AMD) is a leading cause of irreversible, severe vision
loss in Western countries. Recently, we identified a novel pathway involving P2X7 receptor …

As a part of the central nervous system, the retina may reflect both physiological processes
and abnormalities related to pathologies that affect the brain. Amyloidosis due to the …

Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing
significant vision loss. DR is a multifactorial disease involving changes in retinal …

Photoreceptors have high metabolic demands and age rapidly, undermining visual function.
We base our understanding mainly on ageing mice where elevated inflammation …

Inherited retinal degeneration such as retinitis pigmentosa (RP) is associated with
photoreceptor loss and concomitant morphological and functional changes in the inner …

Abstract Amyloid-β (Aβ), reported as a significant constituent of drusen, was implicated in the
pathophysiology of age-related macular degeneration (AMD), yet the identity of the major …