Publisher Summary This chapter discusses the attempts to improve the functional efficacy of
fetal nigral transplants, focusing on three major questions. First, to what extent is it possible …

The striatum is primarily involved in motor planning and motor learning. Human diseases
involving its complex circuitry lead to movement disorders such as Parkinson's disease (PD) …

Dyskinesias are a common consequence of dopaminergic therapy in patients with
Parkinson's disease. Little is known about the influence of cellular replacement strategies …

Graft-induced dyskinesias (GIDs), side-effects found in clinical grafting trials for Parkinson's
disease (PD), may be associated with the withdrawal of immunosuppression. The goal of …

The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-
establish afferent and efferent connections with the host. In this review article, we give an …

Intrastriatal transplantation of dopaminergic neurons can restore striatal dopamine levels
and improve parkinsonian deficits, but the mechanisms underlying these effects are poorly …

OFF-l-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral
mesencephalic transplantation in patients with Parkinson's disease. It has been proposed …

One of the major symptoms of the neurodegenerative condition Parkinson's disease (PD) is
a slowness or loss of voluntary movement, yet frustratingly therapeutic strategies designed …

Previous studies have shown that intrastriatal transplants of dopamine (DA)-rich fetal ventral
mesencephalic (VM) tissue can correct denervation-induced changes in the cellular …

Grafting of ventral mesencephalic tissue in Parkinson's disease results in a partial
dopaminergic reinnervation of host brain and dopamine agonist-induced rotational behavior …