Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …

Stressful events during adulthood are potent adverse environmental factors that can
predispose individuals to psychiatric disorders, including depression; however, many …

Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC)
produces a variety of negative effects with major consequences in cannabis users that …

Rationale Prior reviews have examined how stress, broadly defined, interacts with genetic
diathesis in the pathogenesis of internalizing (ie, depressive and anxiety) disorders. Recent …

In normal life, organisms are repeatedly exposed to brief periods of stress, most of which can
be controlled and adequately dealt with. The presently available data indicate that such brief …

Serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) are implicated in mediating
learned helplessness (LH) behaviors, such as poor escape responding and expression of …

Among psychiatric disorders, depression and generalized anxiety are probably the most
common stress-related illnesses. These diseases are underlain, at least partly, by …

The median (MR) and dorsal raphe (DR) nuclei contain the majority of the 5-
hydroxytryptamine (5-HT, serotonin) neurons that project to limbic forebrain regions, are …