Repurposing FDA-approved drugs against the toxicity of platinum-based anticancer drugs

AC Famurewa, AG Mukherjee, UR Wanjari, A Sukumar… - Life Sciences, 2022 - Elsevier
Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are
widely used efficacious long-standing anticancer agents for treating several cancer types …

Molecular mechanisms associated with chemoresistance in esophageal cancer

M Lohan-Codeço, ML Barambo-Wagner… - Cellular and Molecular …, 2022 - Springer
Esophageal cancer (EC) is one of the most incident and lethal tumors worldwide. Although
surgical resection is an important approach in EC treatment, late diagnosis, metastasis and …

[HTML][HTML] Personalized medicine of non-gene-specific chemotherapies for non-small cell lung cancer

W Jiang, G Cai, P Hu, Y Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Non-small cell lung cancer is recognized as the deadliest cancer across the globe. In some
areas, it is more common in women than even breast and cervical cancer. Its rise, vaulted by …

Recent advances on antitumor agents-loaded polymeric and lipid-based nanocarriers for the treatment of brain cancer

A Cano, M Espina, ML Garcia - Current pharmaceutical design, 2020 - ingentaconnect.com
In 2016, there were 17.2 million cancer cases, which caused 8.9 million deaths worldwide.
Of all cancers, ranked by absolute years of life lost, brain and central nervous system …

More than just DNA damage: Pt (ΙΙ)-NHC complexes derived from 4, 5-diarylimidazoles augment immunogenic cell death

L Tang, X Chang, J Shi, Z Wen, C Bi, W Liu - European Journal of …, 2025 - Elsevier
Platinum-based drugs are a mainstay in chemotherapy, with traditional forms exerting their
work directly on DNA. In recent years, it has been observed that platinum complexes had the …

An Oligonucleotide‐Distortion‐Responsive Organic Transistor for Platinum‐Drug‐Induced DNA‐Damage Detection

D Ye, J Wang, H Shen, X Feng, L Xiang… - Advanced …, 2021 - Wiley Online Library
Organic transistor with DNA‐damage evaluation ability can open up novel opportunities for
bioelectronic devices. Even though trace amounts of drugs can cause cumulative gene …

Andrographolide sensitizes Hep-2 human laryngeal cancer cells to carboplatin-induced apoptosis by increasing reactive oxygen species levels

W Mao, P He, W Wang, X Wu, C Wei - Anti-Cancer Drugs, 2019 - journals.lww.com
Andrographolide is a natural diterpenoid from Andrographis paniculata that has been
proposed as an anticancer agent as well as a chemosensitizer for use in combination with …

Vitamin C protects carboplatin-exposed oocytes from meiotic failure

C Zhou, X Zhang, Y Zhang, X ShiYang… - Molecular human …, 2019 - academic.oup.com
CBP (carboplatin) is a second-generation chemotherapeutic drug of platinum compound
commonly applied in the treatment of sarcomas and germ cell tumours. Although it is …

New anticancer Pt and Pd complexes with binicotinic acid and oxalate derivatives as ligands: Synthesis, cytotoxicity, binding mode on DNA and HSA and molecular …

ME Moghadam, A Jafari, S Shokrollahi - Inorganica Chimica Acta, 2024 - Elsevier
In this project, four new palladium (II) and platinum (II) complexes were designed and
prepared to improve metallo-drugs activity in DNA binding and inhibiting cancerous cells …

[HTML][HTML] The Apportionment of Pharmacogenomic Variation: Race, Ethnicity, and Adverse Drug Reactions

IK Jordan, S Sharma, SD Nagar… - Medical research …, 2022 - ncbi.nlm.nih.gov
Abstract Fifty years ago, Richard Lewontin found that the vast majority of human genetic
variation falls within (~ 85%) rather than between (~ 15%) racial groups. This result has …